Anticholinergic Burden and Cognitive Function, Depressive Symptoms, and Functional Performance in Individuals With Neurocognitive Disorders: Real-World Evidence.

A real-world study examined how anticholinergic drug burden affects cognition, mood, and physical functioning in patients with neurocognitive disorders. Findings suggest that higher cumulative anticholinergic medication loads are associated with worse cognitive performance, increased depressive symptoms, and reduced functional ability in this population. Physical therapists working with patients who have dementia or related conditions should be aware of how polypharmacy—particularly anticholinergic medications—may influence rehabilitation outcomes and functional performance measures.

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