Effects of Exergame Balance Training with Variable Cognitive Motor Challenges on Serum BDNF, p-tau181, and Cognitive Functions in Adults with Mild Cognitive Impairment: A Randomized Trial.

A randomized trial published in Games for Health Journal found that exergame-based balance training incorporating variable cognitive-motor challenges produced measurable changes in serum BDNF and p-tau181 levels, as well as cognitive function outcomes, in adults diagnosed with mild cognitive impairment. These findings suggest that combining interactive video game exercise with dual-task cognitive demands may offer neurobiological benefits beyond standard balance training alone. The results are relevant to PTs designing fall-prevention and cognitive rehabilitation programs for older adults at risk of dementia.

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