Moderate-intensity treadmill exercise improved the anticonvulsant efficacy of topiramate and attenuated anxiety and depressive-like side effects in epileptic rats by upregulating 5-HT1A receptors in the hippocampus and cerebral cortex.

A preclinical study in epileptic rats found that combining moderate-intensity treadmill exercise with the anticonvulsant drug topiramate enhanced seizure control beyond what the medication achieved alone. Exercise also reduced anxiety- and depression-like behaviors that are known side effects of topiramate, with researchers attributing these benefits to upregulation of 5-HT1A serotonin receptors in the hippocampus and cerebral cortex. These findings suggest aerobic exercise may serve as a useful adjunct to pharmacological epilepsy management.

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